What Is NAD+?

What is NAD+ and what relation does it have with aging and health?

NAD+ molecule

NAD+ or Nicotinamide adenine dinucleotide is a common coenzyme found in all living cells. Without the presence of NAD+ fundamental biological functions could not occur on a cellular level and life would cease to exist. NAD+ has several essential roles in metabolism. It acts as a coenzyme in redox reactions that essential allow enzymes within cells to perform functions.

Like how we get energy from nutrients. For this glucose and fatty acids are oxidized, in turn releasing energy. This energy is transferred to NAD+ by reduction to NADH, as part of beta oxidation, glycolyosis and the citric acid cycle.

In Eukaryotes (multi celled organisims) the electron carried by the NADH are transferred to the mitochondria where it is further oxidized in turn by the electron transport chain, which pumps protons across a membrane and generates ATP (adenosine triphosphate) Which is the molecule used to generate energy within cells.

So for cellular redox reactions, NAD+ is the oxidizing agent that takes electrons and NADH is the reducing agent that can give off electrons.

NAD+ is also used in non-redox roles,

A simple example is the way Alcohol Dehydrogenase(ADH) uses NAD+ to oxidize alcohol in the blood to acetylaldehyde, and then ALDH again uses NAD+ to further oxidize acetylaldehyde to Acetic acid or Vinegar which can easily be excreted. This process Reduces NAD+ to NADH.

More to do with aging, other non redox roles are like how NAD+ is consumed by enzymes that are responsible for the regulation of several cellular events within the nucleus of cells, processes such as DNA repair and telomere maintenence.

It is also consumed by sirtuins which are a family of proteins that play a role in aging by regulating cellular health.

*These statements have not been evaluated by the TGA. This product is not intended to diagnose, treat, cure or prevent any disease.